Rasha Abdel Rahman

Prof. Dr.

> Lab-Website
> Email

Affiliation

Humboldt Universität zu Berlin, Department of Psychology, Neurocognitive Psychology, Rudower Chaussee 18, 10099 Berlin, Germany

Research area primary
systems/cognitive

Research Methods
experimental

Research Focus

In our research we use neuroscientific methods (mostly EEG) to investigate basic cognitive processes, with a special interest in the multifaceted aspects of semantic processing. We focus on language production / comprehension, the interface between vision, semantics and language, the functional organisation of semantic memory, attentional, emotional and semantic influences on visual perception, face and object perception, and mental imagery.

Gudrun Ahnert-Hilger

Prof. Dr.

> Lab-Website
> Email

Affiliation

Charité - Universitätsmedizin Berlin, Institute for Integrative Neuroanatomy, RG Functional Cell Biology, Charitéplatz 1, 10117 Berlin

Research area primary
cellular/molecular

Research Methods
experimental
cellular
biochemical

Research Focus

Neuronal communication depends on neurotransmitter storing synaptic vesicles (SV) that following stimulation release their content to the synaptic cleft. Specific vesicular transmitter transporters are responsible for vesicular concentration of glutamate (VGLUT), GABA (VGAT) and monoamines (VMAT) thereby defining phenotype and physiological properties of neuronal subtypes. We are characterizing the regulation of vesicular transmitter transporters by ions and signal transduction molecules like heterotrimeric G-proteins and the impact of the SV protein synaptophysin on transmitter filling.

Malek Bajbouj

Prof. Dr.

> Lab-Website
> Email

Prof. Dr. Malek Bajbouj

Affiliation

Center for Affective Sciences, Department of Psychiatry, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Hindenburgdamm 30, 12203 Berlin

Research area primary
clinical/translational

Research area secondary
systems/cognitive

Research Methods
clinical
cognitive neuroscience
experimental
human brain imaging

Research Focus

Our research group aims at a better understanding of human emotions and affective disorder. To do so, we mainly use multimodal approaches including structural, functional and metabolic imaging, neurophysiology, and brain stimulation techniques. We mainly focus on variations of normal behavior as well as on psychiatric disorders such as depression and postraumatic stress disorder and try to shed light on the role of inherent, cultural, and environmental factors in such conditions.

Felix Bermpohl

Prof. Dr.

> Lab-Website
> Email

Affiliation

Charité - Universitätsmedizin Berlin, Klinik für Psychiatrie und Psychotherapie, CCM, Charitéplatz 1, 10117 Berlin

Research area primary
clinical/translational

Research area secondary
systems/cognitive

Research Methods
experimental
cellular
biochemical

Research Focus

Neural mechanisms of emotions and their interaction with so-called cognitive processes (e.g., self-referential processing, self-control, self-awareness, social cognition, triadic social interactions, decision-making) in healthy individuals and patients with psychiatric disorders (depression, bipolar disorder, substance use disorder, borderline disorder).

Carmen Birchmeier

Prof. Dr.

> Lab-Website
> Email

Prof. Dr. Carmen Birchmeier

Affiliation

Max Delbrück Center for Molecular Medicine, Signal Transduction/Developmental Biology, Robert-Rössle-Str. 10, 13125 Berlin,

Research area primary
cellular/molecular

Research Methods
experimental
molecular

Research Focus

The lab focuses on functional analysis of genes important in development and stem cells, concentrating on muscle, the nervous system and endocrine organs. We observe that many genes control both developmental and regenerative processes in the adult. For our work, we use mouse genetics and stem cells culture, and define molecular mechanisms by genomic and proteomic technologies.

Felix Blankenburg

Prof. Dr.

> Lab-Website
> Email

Affiliation

Freie Universität Berlin , Department of Education and Psychology, Neurocomputation and Neuroimaging Unit, Habelschwerdter Allee 45, 14195 Berlin

Research area primary
systems/cognitive

Research area secondary
clinical/translational

Research Methods
experimental
cognitive neuroscience
modelling
human brain imaging

Research Focus

Action-perception-loop (i.e., interplay between conscious perception, working memory, decision-making, and action); body representation; methods development (incl. model-based EEG/fMRI and multimodal neuroimaging).

Benjamin Blankertz

Prof. Dr.

> Lab-Website
> Email

Affiliation

Technische Universität Berlin, Fachgebiet Neurotechnologie, Sekr. MAR 4-3, Berlin

Research area primary
systems/cognitive

Research area secondary
clinical/translational

Research Methods
experimental
human brain imaging
computational
cognitive neuroscience
machine learning

Research Focus

- machine learning approaches in the field of Brain-Computer Interfacing (BCI) - development of novel experimental paradigms - transfer of BCI technology to real-world applications - brain-based investigation of perception and cognition"

Michael Brecht

Prof. Dr.

> Lab-Website
> Email

Affiliation

Humboldt Universität zu Berlin, Bernstein Center for Computational Neuroscience, Animal Physiology / Systems Neurobiology and Neural Computation, Philippstr. 13 House 6, 10115 Berlin

Research area primary
systems/cognitive

Research area secondary
cellular/molecular

Research Methods
experimental

Research Focus

"Our research group analyses cellular mechanisms underlying sensorimotor integration. The model system we focus on is the active touch/vibrissal system of mammals. We pursue research questions from a strictly systemic, neuroethological perspective. We pose a wide range of questions to understand better the systemic performance of active touch mediated by the vibrissae. We therefore investigate multiple brain structures and our investigations range from intracellular recordings to the analysis of behavioral performance."

Claudia Buss

Prof. Dr.

> Lab-Website
> Email

Prof. Dr. Claudia Buss

Affiliation

Charité - Universitätsmedizin Berlin, Department of Medical Psychology, Charitéplatz 1, 10117 Berlin

Research area primary
clinical/translational

Research area secondary
systems/cognitive

Research Methods
clinical
human brain imaging
epidemiology
biochemical

Research Focus

My research focuses on developmental programming of health and disease risk, with an emphasis on the effects of stress and stress-related biological (maternal-placental-fetal endocrine, immune, genetic) and behavioral (nutrition, physical activity, smoking/drug use) processes during human pregnancy and fetal brain development as well as other health-related infant outcomes. I have expertise in characterizing maternal-placental-fetal stress biology, the quality of key features of the postnatal environment, early neurodevelopmental trajectories and in pediatric neuroimaging.

Radoslaw Martin Cichy

Dr.

> Lab-Website
> Email

Dr. Radoslaw Martin Cichy

Affiliation

Freie Universität Berlin, Department of Education and Psychology, Biological Psychology and Cognitive Neuroscience, Habelschwerdter Allee 45, 14195 Berlin

Research area primary
systems/cognitive

Research Methods
experimental
human brain imaging
computational
cognitive neuroscience

Research Focus

My main interest is human visual cognition – that is, I want to know the brain's representations and algorithms underlying vision. In particular, I want to find out (1) how the brain transforms sensory into abstract representations, (2) the dependency of those representation on task, and (3) the plasticity of the underlying neural architecture studying visual cortex in the blind. I use a combination of methods (fMRI, M/EEG, deep neural networks), and analyze data in an integrated framework using with machine learning techniques and representational similarity analysis.

Gabriel Curio

Prof. Dr.

> Lab-Website
> Email

Prof. Dr. Gabriel Curio

Affiliation

Charité - Universitätsmedizin Berlin, Dept. of Neurology, CBF, Hindenburgdamm 30, 12200 Berlin

Research area primary
systems/cognitive

Research area secondary
clinical/translational

Research Methods
experimental
electrophysiology
cognitive neuroscience

Research Focus

The Neurophysics Group combines neuroscience and physics principles to gain deeper insight into human neuronal processing. Group members discovered and studied in detail ultra-high frequency oscillations in the somatosensory system (400–1200 Hz) which uniquely relate macroscopic non-invasive EEG recordings to single-unit spiking activity. Further research focuses on the development of Brain-Computer Interfaces (www.bbci.de); EEG hardware (miniaturized electrodes; low-noise amplifiers); EEG studies in stroke, epilepsy, and Parkinson’s disease; and on the analysis of speech and music processing.

Ulrich Dirnagl

Prof. Dr.

> Lab-Website
> Email

Prof. Dr. Ulrich Dirnagl

Affiliation

Charité - Universitätsmedizin Berlin, Department of Experimental Neurology, Center for Stroke Research Berlin, Charitéplatz 1, 10117 Berlin

Research area primary
clinical/translational

Research area secondary
cellular/molecular

Research Methods
experimental
clinical

Research Focus

- Regulation of cerebral blood flow and metabolism - Cerebral ischemia and endogenous neuroprotection - Acute brain inflammation, brain - immune interaction - Brain imaging - Quality and predictiveness of translational neuroscience - Meta-research"

Jens Dreier

Prof. Dr.

> Lab-Website
> Email

Prof. Dr. Jens Dreier

Affiliation

Charité - Universitätsmedizin Berlin, Department of Experimental Neurology, Center for Stroke Research Berlin, Charitéplatz 1, 10117 Berlin

Research area primary
clinical/translational

Research Methods
experimental
clinical

Research Focus

Translation of stroke research from bench to bedside, intensive care medicine, ischemic/hemorrhagic stroke, migraine research, in vivo rodent models of ischemic and hemorrhagic stroke, human and rodent brain slices, electrophysiology/neuromonitoring/imaging technology in animals/human.

Isabel Dziobek

Prof. Dr.

> Lab-Website
> Email

Prof. Dr. Isabel Dziobek

Affiliation

Humboldt Universität zu Berlin, Berlin School of Mind and Brain, Social Cognition Group, Luisenstraße 56 (Haus 1), 10117 Berlin

Research area primary
systems/cognitive

Research area secondary
clinical/translational

Research Methods
experimental
cognitive neuroscience
clinical
human brain imaging

Research Focus

▪ Social Cognition, empathy, Theory of Mind, emotion and face recognition ▪ Development and validation of tests and interventions for socio-emotional competencies and empathy ▪ Decision making in social contexts ▪ Kinesthetic empathy and socio-emotional effects of synchronization ▪ Neuronale correlates of social cognition using functional and structural MRI ▪ Social cognition dysfunctions in psychiatric disorders (e.g. autism spectrum conditions, personality disorders, schizophrenia)"

Britta Eickholt

Prof. Dr.

> Lab-Website
> Email

Prof. Dr. Britta Eickholt

Affiliation

Charité - Universitätsmedizin Berlin, Institut für Biochemie, Charitéplatz 1, 10117 Berlin

Research area primary
cellular/molecular

Research area secondary
clinical/translational

Research Methods
experimental
cellular
molecular
biochemical

Research Focus

Our research focuses on the signalling mechanisms that control the dynamic reorganisation of the cytoskeleton during the establishment and maintenance of synaptic connections in the context of brain development and neuronal disorders/disease.

Matthias Endres

Prof. Dr.

> Lab-Website
> Email

Prof. Dr. Matthias Endres

Affiliation

Charité - Universitätsmedizin Berlin, Klinik und Hochschulambulanz für Neurologie, Charitéplatz 1, 10117 Berlin

Research area primary
clinical/translational

Research area secondary
cellular/molecular

Research Methods
clinical
human brain imaging
experimental
molecular

Research Focus

My group is active in the field of stroke research with the following major areas: • preventive vascular mechanisms (endothelial function, physical activity, pharmacology) • mechanisms of cell death (cell cycle activation, DNA damage and repair, apoptosis) • regeneration and functional outcome (cellular plasticity, neurogenesis) • clinical studies (stroke unit, telemedicine)"

Jochen Fiebach

Prof. Dr.

> Lab-Website
> Email

Prof. Dr. Jochen Fiebach

Affiliation

Charité - Universitätsmedizin Berlin, Center for Stroke Research Berlin, CSB Neuroradiology, Hindenburgdamm 30, 12200 Berlin

Research area primary
clinical/translational

Research Methods
clinical

Research Focus

CSB Neuroradiology 3T MRI enables clinical research in hyperacute stroke. Using MRI as primarily diagnostic work up we investigate tissue damage over time, blood brain barrier alterations and prediction of morphological outcome (NCT00715533). LOBI-BBB (NCT02077582) investigates acute stroke patients with a focus on vessel and clot imaging, all types of brain perfusion assessments including vessel size imaging, ASL, resting-state time-shift perfusion, and dynamic susceptibility contrast perfusion. We develop concepts to harmonize patient selection in RCTs.

Carsten Finke

Prof. Dr.

> Lab-Website
> Email

Affiliation

Charité - Universitätsmedizin Berlin, Dept. of Neurology, Berlin School of Mind and Brain, Charitéplatz 1, 10117 Berlin

Research area primary
clinical/translational

Research area secondary
systems/cognitive

Research Methods
clinical
experimental

Research Focus

Our research focuses on the clinical and cognitive neuroscience of memory and memory disorders. We are specifically interested in the pathophysiology of memory deficits in patients with inflammatory brain disorders affecting the medial temporal lobes, including viral and autoimmune encephalitis and patients with paraneoplastic neurological syndromes. We use structural and functional MRI, neuropsychological assessments and psychophysiological measures to investigate the neural mechanisms of memory impairments in these disorders and develop diagnostic and prognostic imaging biomarkers.

Agnes Flöel

Prof. Dr.

> Lab-Website
> Email

Affiliation

Charité - Universitätsmedizin Berlin, Department of Neurology, NeuroCure Clinical Research Center, Charitéplatz 1, 10117 Berlin

Research area primary
clinical/translational

Research area secondary
systems/cognitive

Research Methods
clinical
cognitive neuroscience
experimental
human brain imaging

Research Focus

Research fields - Variability of localization of language and memory functions - Interaction of performance in cognitive tasks with age, genetic factors, and brain morphology - Modulation of learning by interventional strategies (pharmacology, non-invasive electrical brain stimulation, exercise, dietary) in elderly individuals and in patients after brain damage Clinical fields - Cognitive neurology and dementia (vascular and neurodegenerative type) - Stroke and stroke sequelae: rehabilitation of cognitive and motor deficits after stroke"

Craig Garner

Prof. Dr.

> Lab-Website
> Email

Affiliation

DZNE-Berlin, ℅ Charité - Universitätsmedizin Berlin, Campus Charité Mitte, CharitéCrossOver (CCO), Charitéplatz 1, 10117 Berlin

Research area primary
cellular/molecular

Research area secondary
clinical/translational

Research Methods
experimental
cellular imaging
molecular

Research Focus

Our group is focused on understanding the molecular, cellular and physiological mechanisms regulating the dynamic assembly and function of vertebrate CNS synapses. Here we are seeking to define the cellular programs that control the dynamic exchange and degradation of pre- and postsynaptic proteins govern the formation, maintenance and integrity of synapses. We are also interested in understanding how genetic and environmental insults adversely influence these programs, leading to synapse dysfunction and/or neuronal degeneration.

Tengis Glovelli

Prof. Dr.

> Lab-Website
> Email

Affiliation

Charité - Universitätsmedizin Berlin, Institute of Neurophysiology Cellular, Network Physiology Research Group, Charitéplatz 1, 10117 Berlin

Research area primary
cellular/molecular

Research area secondary
systems/cognitive

Research Methods
experimental
electrophysiology
computational
cellular

Research Focus

The goal of our research is to understand how information is processed and encoded in the brain. We use a combination of electrophysiological, anatomical and immunohistological approaches to address the following research questions: • Role of principal cells and interneurons in hippocampal network oscillations • Segregation of axonal and somatic activity during fast network oscillation • Entorhinal cortex-hippocampal physiology and pathophysiology • Impaired hippocampal rhythmogenesis in a mouse model of mesial temporal lobe epilepsy"

Mina Gouti

Dr.

> Lab-Website
> Email

Dr. Mina Gouti

Affiliation

Max Delbrück Center for Molecular Medicine, Stem cell modeling of development and disease, Robert-Rössle-Str. 10, 13125 Berlin

Research area primary
cellular/molecular

Research area secondary
clinical/translational

Research Methods
experimental
cellular
modelling
molecular
Gain and loss of gene function approaches (crispr/cas9 system), single cell genomics(RNA-seq), live cell imaging

Research Focus

We use embryonic stem cells to model embryo development in vitro and understand cell fate choices during neuromuscular system development. We recently generated spinal cord neurons from a neuromesodermal progenitor population. This approach opens up new opportunities for the study of neuromuscular diseases as it gives unprecedented access to the simultaneous development of both neural and mesodermal tissues in the dish. Our focus is to understand how these tissues are generated and interact in space/time during development with the aim to understand the origins of human neuromuscular diseases.

Rosemarie Grantyn

Prof. Dr.

> Lab-Website
> Email

Prof. Dr. Rosemarie Grantyn

Affiliation

Cluster of Excellence Neurocure and Dept. Experimental Neurology University Medicine Charité

Research area primary
cellular/molecular

Research area secondary
systems/cognitive

Research Methods
experimental
cellular
electrophysiology
optogenetics

Research Focus

Our research focuses on astrocyte-related mechanisms in the pathogenesis and treatment of Huntington’s disease. Astrocyte leaflets in proximity to axodendritic release sites are involved in the recycling of neurotransmitters and control the formation, maintenance and plasticity of synaptic domains. Insufficient clearance of glutamate at synaptic sites is considered as a cause of abnormal network activity in the HD striatum. We pursue the aim to ameliorate the motor symptoms of HD by adenoviral gene transfer recovering normal astrocyte-synapse interactions in the corticostriatal pathway.

Christoph Harms

Prof. Dr.

> Lab-Website
> Email

Prof. Dr. Christoph Harms

Affiliation

Charité - Universitätsmedizin Berlin, Department of Experimental Neurology, Center for Stroke Research Berlin, Charitéplatz 1, 10117 Berlin

Research area primary
cellular/molecular

Research area secondary
clinical/translational

Research Methods
experimental
cellular
modelling
super high resolution imaging
behavior, MRI, stroke, glioblastoma, rewiring of the brain, plasticity, inflammation, post-stroke angiogensis, extracellular matrix

Research Focus

We model brain ischemia both in cell culture and in mice. We focus on mechanisms of endogenous neuroprotection and mediators of plasticity and rewiring of networks after focal cerebral ischemia in the long-term. Phenotyping of interventions by gene/ drug delivery, and transgenic models include analyis of behavior and skills training, brain imaging, post-stroke angiogenesis and collaterals, inflammation, network rewiring, transcriptomics, proteomics and high resolution microscopy. Our second focus is glioblastoma and inflammation-targeted personalized therapies using WXS and RNA sequencing.

Volker Haucke

Prof. Dr.

> Lab-Website
> Email

Prof. Dr. Volker Haucke

Affiliation

Leibniz Institut für Molekulare Pharmakologie, Robert-Rössle-Str. 10, 13125 Berlin

Research area primary
cellular/molecular

Research area secondary
systems/cognitive

Research Methods
experimental
molecular
cellular
electrophysiological, biochemical, behavioral, cellular & super-resolution imaging

Research Focus

From sensory perception to learning and memory, the functioning of the nervous system is dependent upon communication between neurons. Dysfunction of neuronal signaling results in neurological and neurodegenerative disorders ranging from autism to epilepsy and Alzheimer's disease. The focus of research in the Haucke laboratory is the dissection of the molecular mechanisms of exo-endocytosis and endolyososomal membrane dynamics and its role neurotransmission and neurodevelopment (Kononenko & Haucke, Neuron 2015) as well as in the aging brain.

Anja Erika Hauser

Prof. Dr.

> Lab-Website
> Email

Affiliation

Charité - Universitätsmedizin Berlin, Deutsches Rheumaforschungszentrum, Charitéplatz 1, 10117 Berlin

Research area primary
cellular/molecular

Research area secondary
clinical/translational

Research Methods
experimental
molecular
clinical
small animal imaging

Research Focus

My research focuses on how the immune system interacts with tissue-specific cells during inflammatory processes. The lab is particularly interested in elucidating the mechanisms of chronic neuroinflammation. We are analysing the dynamics of immune responses in vivo, using intravital microscopy in various mouse models, with the aim to identify novel therapeutic approaches targeting chronic inflammation.

John-Dylan Haynes

Prof. Dr.

> Lab-Website
> Email

Affiliation

Charité - Universitätsmedizin Berlin, Bernstein Center for Computational Neuroscience

Research area primary
systems/cognitive

Research area secondary
systems/cognitive

Research Methods
experimental
cognitive neuroscience
computational
human brain imaging

Research Focus

- Cognitive neuroscience of visual perception, attention, decision making and awareness. - Cognitive neuroscience of intentions, executive functions and free will. - Brain imaging methjods, multivariate analyses, pattern calssicfication and brain reading.

Hauke Heekeren

Prof. Dr.

> Lab-Website
> Email

Affiliation

Freie Universität Berlin, Department of Education and Psychology, Biological Psychology and Cognitive Neuroscience, Habelschwerdter Allee 45, 14195 Berlin

Research area primary
systems/cognitive

Research Methods
experimental
computational

Research Focus

I am interested in the cognitive neuroscience of human decision making. My research group studies basic mechanisms of perceptual, value-based, and social decision making using behavioral methods, cognitive modeling as well as human brain imaging methods (such as fMRI and EEG)

Peter Hegemann

Prof. Dr.

> Lab-Website
> Email

Affiliation

Humboldt Universität zu Berlin, Exp. Biophysik, Invalidenstr. 42, 10117 Berlin

Research area primary
cellular/molecular

Research Methods
experimental
biochemical
electrophysiology
optogenetics

Research Focus

my group works primarily on the molecular characterization of natural sensory photoreceptors including flavin-based receptors and unusual microbial rhodopsins. Several of them including channelrhodopsin that we discovered and intensively characterized are now widely applied in the neurosciences as optogentic actuators. We are are engineering many derivatives with modified absorption, kinetics and ion- or substrate selectivities and work on neuronal applications and studies in collaborations for example with Matthew Larkum, Andrew Plested, Christian Rosenmund, Dietmar Schmitz.

Andreas Heinz

Prof. Dr.

> Lab-Website
> Email

Prof. Dr. Andreas Heinz

Affiliation

Charité - Universitätsmedizin Berlin, Department of Psychaitry and Psychotherapy, CCM, Charitéplatz 1, 10117 Berlin

Research area primary
systems/cognitive

Research area secondary
clinical/translational

Research Methods
experimental
human brain imaging
computational

Research Focus

My group is active in thr field of monoaminergic dysfunction in psychiatric disorders, combining genetic research, and multimodal brain imaging techniques, with the following major areas: - monoaminergic dysfunction in neuropsychiatric disorders, e.g. dopaminergic dysfunction in alcoholism und schizophrenia - genotype effects on neuroeceptor binding and functional activation in brain imaging - multimodal brain imaging in psychiatry (PRT, SPECT, fMIR, MRS) - concepts of reward, punishment, and motivation in philosophy, neuoscience, and transcultural psychiatry

Frank Heppner

Prof. Dr.

> Lab-Website
> Email

Prof. Dr. Frank Heppner

Affiliation

Charité - Universitätsmedizin Berlin, Department of Neuropathology, Charitéplatz 1, 10117 Berlin

Research area primary
cellular/molecular

Research area secondary
clinical/translational

Research Methods
experimental
cellular
modelling
molecular
Neuroimmune interface

Research Focus

Our group is active in the field of experimental and clinical neuropathology & neuroscience with the following major areas: • Immunological aspects of neurological disorders such as neurodegenerative diseases • the neuroimmune interface: how the immune system impacts neural networks & homeostasis • Impact of neuroinflammation on systemic metabolism • Biology of the microglia"

Hans-Peter Herzel

Prof. Dr.

> Lab-Website
> Email

Prof. Dr. Hans-Peter Herzel

Affiliation

Humboldt Universität zu Berlin, Institute for Theoretical Biology, Philippstr. 13, 10115 Berlin

Research area primary
cellular/molecular

Research area secondary
systems/cognitive

Research Methods
computational
molecular
modelling
cellular

Research Focus

The focus of our theoretical group is the coordination of circadian rhythms in mammals. In common projects with Achim Kramer (Charite), Toru Takumi (Riken Brain Science Institute) and Erik Herzog (Neuroscience Program WashU) we study the synchronization of neurons in the suprachiasmatic nucleus (SCN). We study the underlying genetic networks, model the SCN as a system of coupled oscillators, and explore the mechanisms of chronotype diversity and seasonal encoding. Our approach is based on data analysis methods, differential equation models and bioinformatics.

Peter Robin Hiesinger

Prof. Dr.

> Lab-Website
> Email

Affiliation

Freie Universität Berlin, Department of Biology, Chemistry, Pharmacy, Institute of Biology, Königin-Luise-Str. 28-30, Berlin

Research area primary
cellular/molecular

Research Methods
experimental
molecular
computational
cellular imaging

Research Focus

Our group is active in the field of cellular and molecular neurobiology with the following major areas: - Cellular and molecular mechanisms of synapse specification and brain wiring - Cellular and molecular mechanisms of synaptic maintenance and neurodegeneration We use the model organism Drosophila.

Martin Holtkamp

Prof. Dr.

> Lab-Website
> Email

Prof. Dr. Martin Holtkamp

Affiliation

Charité - Universitätsmedizin Berlin, Department of Neurology, Clinical and Experimental Epileptology, Charitéplatz 1, 10117 Berlin

Research area primary
cellular/molecular

Research area secondary
clinical/translational

Research Methods
experimental
electrophysiology
clinical
cognitive neuroscience

Research Focus

In our group, we combine clinical and experimental epilepsy research. Our clinical research focuses on epidemiology and deep brain stimulation, but also on cognitive studies in patients with intracranial electrodes. Experimentally, we tackle pathophysiological questions in various types of epilepsy and look for new therapeutic approaches using mainly in vitro electrophysiology in rodent and human brain slices and in vivo studies in rodents. Overall, we aim for translation of our experimental/clinical findings into patient care and for an improvement of the quality of life in epilepsy patients.

Carmen Infante Duarte

PD. Dr.

> Lab-Website
> Email

Affiliation

Charité - Universitätsmedizin Berlin, Experimental and Clinical Research Center, Institute for Medical Immunology

Research area primary
cellular/molecular

Research area secondary
clinical/translational

Research Methods
experimental
cellular
clinical
molecular
animal models of inflammation

Research Focus

Our research interest focuses on the pathogenesis of autoimmune neuroinflammation. We aim to understand how the immune system, in particular its innate components, contributes to neurodegeneration or regulates inflammation, using the animal model of Multiple Sclerosis (MS), the experimental autoimmune encephalomyelitis (EAE) as well as ex vivo nerve cultures. Moreover, we have been working on the development of novel therapeutic and diagnostic options (principally MR-based approaches) and on the identification of biomarkers for monitoring therapy response in neuroinflammation.

Friedrich Johenning

PD. Dr.

> Lab-Website
> Email

PD. Dr. Friedrich Johenning

Affiliation

Charité - Universitätsmedizin Berlin, Neurowissenschaftliches Forschungszentrum, Charitéplatz 1, 10117 Berlin

Research area primary
cellular/molecular

Research area secondary
clinical/translational

Research Methods
experimental
electrophysiology
cellular imaging

Research Focus

How does calcium signaling transduce electrical neuronal activity into long-lasting structural and functional changes affecting plasticity and development of synapses and neuronal circuits? • Methods I use: Calcium imaging (confocal and 2P), 1P and 2P glutamate uncaging, static and dynamic morphometry of dendrites and spines, electrophysiology, circuit mapping, acute brain slices • Brain Regions I am interested in: Olfactory (piriform) cortex and hippocampal formation. • Disease models I am interested in: Fragile X Syndrome, GLUK2 KO Model of MR.

Benjamin Judkewitz

Prof. Dr.

> Lab-Website
> Email

Prof. Dr. Benjamin Judkewitz

Affiliation

Charité - Universitätsmedizin Berlin, Neurowissenschaftliches Forschungszentrum, NeuroCure, Charitéplatz 1, 10117 Berlin

Research area primary
systems/cognitive

Research Methods
experimental
small animal imaging
computational
cellular imaging

Research Focus

The Bioimaging and Neurophotonics lab is part of the NeuroCure Cluster of the German Excellence Initiative. We develop and apply new techniques that overcome optical scattering, in order to enable neuronal population imaging and optical stimulation at unprecedented depths in biological tissue.

Angela Kaindl

Prof. Dr.

> Lab-Website
> Email

Prof. Dr. Angela Kaindl

Affiliation

Charité - Universitätsmedizin Berlin, Institute for Cell and Neurobiology, Center for Chronically Sick Children (SPZ), 10117 Berlin

Research area primary
clinical/translational

Research area secondary
cellular/molecular

Research Methods
clinical
molecular
experimental
cellular

Research Focus

The Kaindl Lab focuses on the characterization of novel phenotypes associated with hereditary or acquired CNS malformation and their underlying pathomechanisms. In clinical projects, we recruit and phenotype patients with CNS malformations in particular with microcephaly, have set up a patient database, analyzed the efficiency of the current approach to patients and published diagnostic standards. In translational projects, we identified mutations in so-far not disease-associated genes in these patients and functionally analyze them with repsect to the phenotype.

Richard Kempter

Prof. Dr.

> Lab-Website
> Email

Affiliation

Humboldt Universität zu Berlin, Institute for Theoretical Biology, Bernstein Center for Computational Neuroscience, Phillipstr. 13, House 4, 10115 Berlin

Research area primary
cellular/molecular

Research area secondary
systems/cognitive

Research Methods
computational
cellular
modelling
electrophysiology

Research Focus

Richard Kempter leads the research group Theoretical Neuroscience at the HU Berlin. Research focuses on the neural basis of learning and memory, and involves computational and mathematical modeling of synapses, neurons, and networks of neurons. Of particular interest is short-term and long-term plasticity in the auditory system and the hippocampus

Helmut Kettenmann

Prof. Dr.

> Lab-Website
> Email

Affiliation

Max Delbrück Center for Molecular Medicine, Department of Neuroscience, Robert-Rössle-Str. 10, 13092 Berlin

Research area primary
cellular/molecular

Research Methods
experimental
cellular
electrophysiology

Research Focus

Our goal is to understand the role of glial cells in physiology and pathology. The present research program is focused on four topics: (1) the extent of gap junction coupling within the glial network and its impact on brain function (2) the functional expression of transmitter receptors in microglia (3) the response of microglial cells to brain injury and (4) the interaction of gliomas with microglia and astrocytes.

Ursula Koch

Prof. Dr.

> Lab-Website
> Email

Prof. Dr. Ursula Koch

Affiliation

Freie Universität Berlin, Fachbereich Biologie, Chemie, Pharmazie, Neurobiologie und Verhalten, AG Neurophysiologie, Berlin

Research area primary
systems/cognitive

Research area secondary
cellular/molecular

Research Methods
experimental
electrophysiology
cellular

Research Focus

My research group studies the development and function of neural circuits in the brain that process acoustic information. We are interested how neural circuits in the auditory brainstem are formed and refined during development and to what extent environmental factors (e.g. noise or nicotine exposure) perturb this proper development. Moreover, we use desease mouse model to understand the changes in auditory brainstem circuitry underlying the altered sensory perception in developmental disorders such as autism spectrum disorders.

Achim Kramer

Prof. Dr.

> Lab-Website
> Email

Affiliation

Charité - Universitätsmedizin Berlin, Institut für Medizinische Immunologie, Arbeitsbereich Chronobiologie, Hessische Str. 3-4, 10115 Berlin

Research area primary
cellular/molecular

Research area secondary
systems/cognitive

Research Methods
experimental
biochemical
cellular imaging

Research Focus

Our group is engaged in understanding the molecular basics of the circadian clockwork in mammals and their impact on physiological and behavioral processes. We are studying the regulation of intracellular processes which generate circadian oscillations with biochemical, molecular- and cell-biological methods.

Elke Krüger

Prof. Dr.

> Lab-Website
> Email

Affiliation

Charité - Universitätsmedizin, Institute of Biochemistry, Charitéplatz 1, 10117 Berlin

Research area primary
cellular/molecular

Research Methods
experimental
molecular
cellular

Research Focus

prosteostasis in neurodegenreation and neuroinflammation

Matthew Larkum

Prof. Dr.

> Lab-Website
> Email

Prof. Dr. Matthew Larkum

Affiliation

Humboldt Universität zu Berlin, Institute of Biololgy, NeuroCure, Charitéplatz 1, 10117 Berlin

Research area primary
systems/cognitive

Research area secondary
cellular/molecular

Research Methods
experimental
molecular
computational
molecular

Research Focus

We investigate the computational power of single neurons and their contribution to cortical function. Our main hypothesis is that an associative mechanism is built into the cortex at the cellular level – dendritic spikes in pyramidal neurons. We explore this hypothesis on many levels using a variety of research techniques: multiple dendritic patch-clamp recordings in vitro, extracellular electrophysiological techniques, calcium imaging, somatic and dendritic patch-clamp recordings in vivo, two photon imaging (in vitro and in vivo), rodent behavioural experiments and optogenetic app

Gary Lewin

Prof. Dr.

> Lab-Website
> Email

Affiliation

Max Delbrück Center for Molecular Medicine, Department of Neuroscience, Robert-Rössle-Str. 10, 13125 Berlin

Research area primary
cellular/molecular

Research area secondary
systems/cognitive

Research Methods
experimental
molecular
electrophysiology
mechanotransduction

Research Focus

Sensory neurons of the dorsal root ganglia allow us to detect stimuli to the body surface that lead directly to the sensations such as touch and pain. We explore the genes that allow these neurons to transduce different types of stimuli. We study in detail the process of mechanotransduction which requires mechanosensitive ion channels. Discovery of mechanotransduction molecules and elucidating their role in health and disease is a central interest of my lab.

Benjamin Linder

Prof. Dr.

> Lab-Website
> Email

Prof. Dr. Benjamin Linder

Affiliation

Humboldt Universität zu Berlin, Department of Physics, AG Theory of Complex Systems and Neurophysics, Philipstr. 13, House 2, 10115 Berlin

Research area primary
cellular/molecular

Research Methods
computational
modelling

Research Focus

We explore simplified biophysical models of the spontaneous activity and transmission of time-dependent signals in single nerve cells, in small populations and in recurrent networks of spiking neurons. In close collaboration with experimental groups, we focus on aspects related to the stochastic and nonlinear dynamics of neurons, such as spatial and temporal noise correlations, cellular and population-based mechanisms of information filtering, and the emergence of slow processes at the network level.

Halina Machelska

Prof. Dr.

> Lab-Website
> Email

Affiliation

Charité - Universitätsmedizin Berlin, Department of Anesthesiology and Intensive Care Medicine, Hindenburgdamm 30, 12203 Berlin

Research area primary
cellular/molecular

Research area secondary
clinical/translational

Research Methods
experimental
cellular
biochemical
in vivo rodent models

Research Focus

Pathophysiology of chronic pain (inflammatory, neuropathic, postoperative, arthritis) Cellular and translational approaches in pain modulation Neuroimmune interactions for pain control Neuropharmacology, nanopharmacology (opioids, ion channels) Nonpharmacological, noninvasive approaches for pain treatment

Andreas Meisel

Prof. Dr.

> Lab-Website
> Email

Prof. Dr. Andreas Meisel

Affiliation

Charité - Universitätsmedizin Berlin, Department of Neurology, NeuroCure Clinical Research Center NCRC/Center for Stroke Research Berlin CSB, Charitéplatz 1, 10117 Berlin

Research area primary
clinical/translational

Research area secondary
cellular/molecular

Research Methods
experimental
molecular
clinical
cellular
murine experimental models of stroke and myasthenia gravis

Research Focus

My group is active in experimental and clinical research investigating pathophysiological mechanisms and novel treatment approaches in stroke, neuromuscular and neurointensive disorders. - Mechanisms and functional relevance of CNS injury-induced immunodepression - Endogenous mechanisms of metabolic stress response - Novel diagnostic biomarkers and strategies for treatment of post-stroke complications - Clinical trials in immunomodulation of stroke and its complications as well as Myasthenia gravis

Stefan Mergler

PD. Dr.

> Lab-Website
> Email

PD. Dr. Stefan Mergler

Affiliation

Charité - Universitätsmedizin Berlin, Department of Ophthalmology, Augustenburger Platz 1, 13353 Berlin

Research area primary
cellular/molecular

Research Methods
experimental
electrophysiology
Patch-Clamp/Ca2+ Imaging

Research Focus

Experimental ophthalmology and TRP channel research - Polymodal roles of transient receptor potential channels in the control of ocular function - Ocular transient receptor potential channel function in health and disease - Temperature-sensitive transient receptor potential channels in corneal tissue layers and cells - Transient receptor potential channels in uveal melanoma

Klaus-Robert Müller

Prof. Dr.

> Lab-Website
> Email

Affiliation

Technische Universität Berlin, Institute for Software Engineering and Theoretical Computer Science, Department for Machine Learning, Marchstr. 23, 10587 Berlin

Research area primary
cellular/molecular

Research area secondary
clinical/translational

Research Methods
computational
human brain imaging
experimental
cognitive neuroscience

Research Focus

statistical learning theory (Support Vector Machines, Deep Neural Networks, Boosting), learning of nonstationarity data, fusion of structured heterogeneous multi-modal data, co-adaptation. Applications: MEG, EEG, NIRS, ECoG, EMG, Brain Computer Interfaces, computational neuroscience, computer vision, genomic data analysis, computational chemistry and atomistic simulations

Klaus Obermayer

Prof. Dr. Prof. Dr.

> Lab-Website
> Email

Affiliation

Technische Universität Berlin, Fakultät IV (Elektrotechnik und Informatik), Berlin

Research area primary
systems/cognitive

Research Methods
computational

Research Focus

In collaboration with experimental neuroscientists we study how the visual system processes information. Research topics include: neural dynamics, adaptation & coding. More recently we began to study models of reward-based learning and decision making in order to understand how these processes interact with perception and memory. This includes computational models to study the macroscopic brain dynamics including the effects of non-invasive stimulation. We also develop machine learning methods for pattern recognition and reinforcement learning and apply them to the analysis of biomedical data.

Manfred Opper

Prof. Dr.

> Lab-Website
> Email

Affiliation

Technische Universität Berlin, Fakultät IV (Elektrotechnik und Informatik), Marchstr. 23, 10587 Berlin

Research area primary
systems/cognitive

Research Methods
computational
modelling

Research Focus

Machine learning, Bayesian probabilistic modeling and artificial intelligence with background in theoretical (statistical) physics. Main application area: Statistical inference of stochastic dynamical systems. Applications to Computational Neuroscience: Inference of neural connectivity from spike train data using dynamical models. Models of optimal neural encoding for control and estimation.

Christian Otte

Prof. Dr.

> Lab-Website
> Email

Affiliation

Charité - Universitätsmedizin Berlin, Klinik für Psychiatrie und Psychotherapie, CBF, Hindenburgdamm 30, 12203 Berlin

Research area primary
clinical/translational

Research area secondary
systems/cognitive

Research Methods
experimental

Research Focus

Major Depression, Posttraumatic Stress Disorder, Early Life Adversity, Stress, Glucocorticoids, Cognition, Cardiovascular and metabolic health in psychiatric patients, Psychopharmacology

David Owald

Dr.

> Lab-Website
> Email

Affiliation

Charité - Universitätsmedizin Berlin, Institute of Neurophysiology, Charitéplatz 1, 10117 Berlin

Research area primary
cellular/molecular

Research area secondary
systems/cognitive

Research Methods
experimental

Research Focus

Our research focusses on olfactory memories in the fruit fly. The fruit fly has a relatively small yet complex enough brain and offers unrivaled genetic control and means of intervention allowing for studying neural activity at the level of single neurons. We combine anatomy, genetics, functional 2 photon imaging, electrophysiology, superresolution microscopy, and optogenetics with behavioral approaches to identify and tackle the circuits, synapses and the molecular basis of memory and reinforcement learning.

Michael Pauen

Prof. Dr.

> Lab-Website
> Email

Prof. Dr. Michael Pauen

Affiliation

Berlin School of Mind and Brain, Department of Philosophy, Humboldt Universität zu Berlin

Research area primary

Research Methods
Philosophy

Research Focus

Philosophy of Mind Free will Consciousness Consequences and implications of neuroscientific research

Friedemann Paul

Prof. Dr.

> Lab-Website
> Email

Affiliation

Charité - Universitätsmedizin Berlin, NeuroCure Clinical Research Center, ECRC Charitéplatz 1, 10117 Berlin

Research area primary
clinical/translational

Research Methods
clinical
human brain imaging
experimental
super high resolution imaging

Research Focus

Diagnosis and differential diagnosis of autoimmune central nervous system disorders with the help of advanced imaging techniques (such as advanced MRT at 3T and 7T, optical coherence tomography), pathophysiology of visula system damage in autoimmune CNS conditions, clinical trial autocomes, neuroprotective therapies for multiple sklerosis and related conditions.

Andrew Plested

Dr.

> Lab-Website
> Email

Dr. Andrew Plested

Affiliation

Leibniz Institut für Molekulare Pharmakologie, Cluster of Excellcence NeuroCure, Robert-Rössle-Str. 10, 13125 Berlin

Research area primary
cellular/molecular

Research Methods
experimental
molecular
electrophysiology

Research Focus

In my group we study the molecular mechanisms of neurotransmitter receptors. We study glutamate receptors in expression systems, and more recently, at central synapses. We employ electrophysiology, structural biology, optical methods and biochemistry to pursue diverse goals. We are interested to know how receptors are activated by glutamate, how their behaviour relates to cognition and memory storage and how we can control and visualize synaptic transmission with light.

Christoph J. Ploner

Prof. Dr.

> Lab-Website
> Email

Affiliation

Charité - Universitätsmedizin Berlin, Klinik für Neurologie, AG Brain & Behavior, Augustenburger Platz 1, 13353 Berlin

Research area primary
systems/cognitive

Research area secondary
clinical/translational

Research Methods
experimental
clinical

Research Focus

My research focusses on visual perception and memory in patients with focal lesions of the frontal cortex, thalamus and temporal lobe, with a focus on memory functions of the medial temporal lobe, i.e. hippocampus and adjacent cortex. Methods are mainly behavioral, but also include structural and functional MRI, psychophysics, questionnaires, transcranial magnetic stimulation and neuropsychology. I am particularly interested in the organization of musical memory and contributions of medial temporal lobe subregions to memory, which we currently investigate by combining lesion studies with fMRI.

James Poulet

Dr.

> Lab-Website
> Email

Affiliation

Max Delbrück Center for Molecular Medicine (MDC); Cluster of Excellence NeuroCure

Research area primary
systems/cognitive

Research area secondary
cellular/molecular

Research Methods
experimental
electrophysiology
cellular imaging
behavior

Research Focus

Our goal is to understand neural mechanisms of sensory processing and perception. We focus on brain regions associated with sensing and movement of the mouse forepaw, with a special focus on neocortical circuits. To investigate the link between neural activity and sensory perception we record and manipulate genetically identified neurons in mice performing trained behavioural tasks.

Josef Priller

Prof. Dr.

> Lab-Website
> Email

Affiliation

Charité - Universitätsmedizin Berlin, Department of Neuropsychiatry, Laboratory of Molecular Psychiatry, Charitéplatz 1, 10117 Berlin

Research area primary
clinical/translational

Research area secondary
cellular/molecular

Research Methods
experimental
molecular
experimental
molecular

Research Focus

Organic psychiatry, neurodegenerative diseases, regenerative medicine, neuroimmunology

Harald Prüß

PD. Dr.

> Lab-Website
> Email

Affiliation

Charité - Universitätsmedizin Berlin, Department of Neurology, German Center for Neurodegenerative Diseases, Charitéplatz 1, 10117

Research area primary
clinical/translational

Research area secondary
cellular/molecular

Research Methods
experimental
molecular
clinical
biochemical

Research Focus

Auto-antibodies against the nervous system cause a wide range of neuropsychiatric disorders from encephalitis to dementia to psychosis. We identify the underlying antibodies and their molecular targets, study the disease mechanisms and model the functional effects in vitro and in vivo. Experimental results provide insight into the molecular cascades of neuronal damage, thus representing an important translational approach to identify patients that could benefit from immunotherapy.

Friedemann Pulvermüller

Prof. Dr.

> Lab-Website
> Email

Prof. Dr. Friedemann Pulvermüller

Affiliation

Freie Universität Berlin, Department of Philosophy & Humanities, Habelschwerdter Allee 45, 14195 Berlin

Research area primary
systems/cognitive

Research Methods
experimental
electrophysiology
computational
cognitive neuroscience
clinical (RCTs)

Research Focus

- neurobiology of language - brain theory and neurocomputational medeling of cognitive functions - brain mechanisms for speech sounds, stored emaningfull units, construction & combinations - brain basis of language use for communication - neurorehabilitation of language

Petra Ritter

PD. Dr.

> Lab-Website
> Email

PD. Dr. Petra Ritter

Affiliation

Charité - Universitätsmedizin Berlin, Berlin

Research area primary
systems/cognitive

Research area secondary
clinical/translational

Research Methods
computational
human brain imaging
experimental
cognitive neuroscience

Research Focus

Dr. Ritter’s research program addresses multi-scale computations in the human brain by combining multimodal neuroimaging and computational modeling. With the recently awarded renowned ERC consolidator grant Dr. Ritter continues to contribute to the integration of knowledge about the brain in a comprehensive unifying computational framework – The Virtual Brain (TVB) of which she is co-founder. TVB is a unique simulation tool that integrates experimental data in a mathematical model of the brain and allows for personalized predictions of healthy and pathological brain function.

Martin Rolfs

Dr.

> Lab-Website
> Email

Affiliation

Humboldt Universität zu Berlin, Department of Psychology, Bernstein Center for Computational Neuroscience Berlin, Active Vision and Cognition Group, Philippstr. 13, 10115 Berlin

Research area primary
systems/cognitive

Research area secondary
clinical/translational

Research Methods
experimental
molecular
modelling
molecular

Research Focus

We asses the architecture and plasticity of perceptual and sensorimotor processes in active vision and cognition, using eye tracking, motion tracking, psychophysics, computational modeling, EEG, and studies of clinical populations. Our research builds on the recognition that any deep understanding of the mind´s basic functions requires studying its key processes - perception, attention, working memory - in observers that actively behave in their environment.

Nina Romanczuk-Seifert

Prof.Dr.

> Lab-Website
> Email

Prof.Dr. Nina Romanczuk-Seifert

Affiliation

Charité - Universitätsmedizin Berlin, Department of Psychiatry and Psychotherapy, Charitéplatz 1, 10117 Berlin

Research area primary
systems/cognitive

Research area secondary
clinical/translational

Research Methods
clinical
human brain imaging
experimental
cognitive neuroscience

Research Focus

My research group "Emotional Neuroscience" has a focus on neurobiological correlates of emotion and reward processing as well as reward-associated learning and decision-making. We use neuroscientific methods such as MRI to assess the neurobiology of psychiatric disorders and its relation to psychopathology and neuropsychological functions. Heading for a retranslation of neuroscientific research into clinical practise we are also interested in the neurobiological mechanisms of therapeutic change

Christian Rosenmund

Prof. Dr.

> Lab-Website
> Email

Affiliation

Charité - Universitätsmedizin Berlin, Institute of Neurophysiology, Charitéplatz 1, 10117 Berlin

Research area primary
cellular/molecular

Research Methods
experimental
electrophysiology

Research Focus

Our laboratory studies basic principles of synaptic transmission with a major focus on the process of neurotransmitter release. We use electrical and optical recording techniques to study synapses in their function and plasticity. We also use light and electron microscopy to study the structure of synapses and how these structures change during plastic events and under pathophysiological conditions.

Constance Scharff

Prof. Dr.

> Lab-Website
> Email

Prof. Dr. Constance Scharff

Affiliation

Freie Universität Berlin Institut für Biologie, Verhaltensbiologie, Takustr. 6, 14195 Berlin

Research area primary
cellular/molecular

Research area secondary
systems/cognitive

Research Methods
experimental

Research Focus

Our group researches the cellular and molecular neurobiology of learned behaviors, with the following major areas: - Cellular and molecular mechanisms of vocal communication and its disorders - Deep homologies in speech/language and animal communication; molecular evolution of gene networks relevant for vocal learning and its disorders - Mechanisms and functions of adult neurogenesis

Dietmar Schmitz

Prof. Dr.

> Lab-Website
> Email

Prof. Dr. Dietmar Schmitz

Affiliation

Charité - Universitätsmedizin Berlin, Neuroscience Research Center, Charitéplatz 1, 10117 Berlin

Research area primary
cellular/molecular

Research area secondary
systems/cognitive

Research Methods
experimental
cellular
electrophysiology

Research Focus

Our group is active in the field of cellular and systems neuroscience with the following major areas: *Mechanisms of synaptic plasticity *Modulation and development of synaptic transmission, plasticity, and neuronal networks *‘Synaptopathy’ and circuit dysfunction in neuropsychiatric disorders

Susanne Schreiber

Prof. Dr.

> Lab-Website
> Email

Affiliation

Humboldt Universität zu Berlin, Department of Biology, Institute for Theoretical Biology, Philippstr. 13, House 4, 10115 Berlin

Research area primary
cellular/molecular

Research area secondary
systems/cognitive

Research Methods
computational
modelling

Research Focus

We investigate signal processing from single neurons to networks. In particular, we seek to understand how neurons are optimized for their computational task. Therefore, we investigate the relationship between intrinsic neuronal properties and the signaling mechanisms shaped by them, as well as their relevance for network behavior. The aim is to link the molecular level of ion channels to characteristics of neuronal firing, focusing on topics like spike-timing reliability, synchronization, information transfer, and energy efficiency.

Torsten Schubert

Prof. Dr.

> Lab-Website
> Email

Affiliation

Humboldt Universität zu Berlin, Institute for Psychology, Unter den Linden 6, 10117 Berlin

Research area primary
systems/cognitive

Research Methods
experimental
modelling

Research Focus

Executive control in action and cognition, functions of working memory and attention in the healthy and neurologically impaired brain, mechanisms of multitasking and its modulation Mechanisms of non-conscious information processing and its influence on perception and action Functional Magnetic Resonance Imagery, functional neuroanatomy of cognition and action Cognitive and neural plasticity: training- and practice-related changes of cognitive functions; mechanisms and limitations of cognitive training Disease-related and age-related influences on cognitive and brain functions

Markus Schülke

Prof. Dr.

> Lab-Website
> Email

Affiliation

Charité - Universitätsmedizin Berlin, Department of Neuropediatrics, Children's Hospital, NeuroCure Clinical Research Center, Charitéplatz 1, 10117 Berlin

Research area primary
clinical/translational

Research area secondary
cellular/molecular

Research Methods
clinical
cellular imaging
computational
molecular
bioinformatics

Research Focus

My research focuses on the discovery of novel genetic defects that cause inherited disorders of the nervous system and of neurodevelopment. For that we use exome and whole genome sequencing techniques and modern bioinformatic tools such as HomozygosityMapper and MutationTaster, which have been developed by our group. Once found, these novel disease genes are characterized with regard to their function and pathophysiology with cell and animal models using molecular genetic and high resolution microscopic imaging techniques.

Sarah Shoichet

Prof. Dr.

> Lab-Website
> Email

Affiliation

Charité - Universitätsmedizin Berlin, Institute of Biochemistry, Charitéplatz 1, 10117 Berlin

Research area primary
cellular/molecular

Research area secondary
clinical/translational

Research Methods
experimental
molecular
biochemical
cellular

Research Focus

In our lab, we investigate the molecular basis of neurological disorders, with a primary focus on the genetic and molecular cascades underlying neurodevelopmental disturbances. We combine molecular genetics with pharmacological and imaging strategies to explore the function of selected neuronal proteins that have been implicated in autism or related diseases through human genetic studies. The aim is to contribute to our understanding of how these diverse proteins interact and regulate each other to influence neuron differentiation, synaptogenesis, and synaptic function and plasticity.

Stephan Sigrist

Prof. Dr.

> Lab-Website
> Email

Affiliation

Freie Universität Berlin , Fachbereich Biologie, Chemie, Pharmazie, Institut für Biologie, Genetik, Takustr. 6, 14195 Berlin

Research area primary
cellular/molecular

Research area secondary
clinical/translational

Research Methods
experimental
molecular
super high resolution imaging

Research Focus

The research of the Sigrist Laboratory has provided fundamental insights into the mechanims of how synapses assemble their particular protein architectures to disply their specific functions. Our group is known for the innovative use of new imaging techniques, particularly super-resolution light microscopy and intravital live imaging of synaptic protein dynamics. We currently establish causal links at the crossroads synapse biology and age-induced memory decline, a considerable medical and socioeconomic problem of our societies.

Werner Sommer

Prof. Dr.

> Lab-Website
> Email

Affiliation

Humboldt Universität zu Berlin, Institut of Psychologie, 10117 Berlin

Research area primary
systems/cognitive

Research Methods
experimental
electrophysiology
cognitive neuroscience

Research Focus

I study cognitive and emotional processes with biological and behavioral methods. Currently my main interests are indvidual differences and life span development in face identity processing and emotion recognition and production in faces, the psychology of food and meals, reading, (oculo-)motor processes, and method development for EEG analyses. My main research methods are EEG, eye tracking (also in combination), and behavioral.

Henning Sprekeler

Prof. Dr.

> Lab-Website
> Email

Affiliation

Technische Universität Berlin, Department of Electrical Engineering and Computer Science, Modeling of Cognitive Processes, Marchstr. 23, 10587 Berlin

Research area primary
systems/cognitive

Research area secondary
cellular/molecular

Research Methods
computational
molecular
modelling
molecular

Research Focus

We study the mechanisms that underlie information processing in neural circuits, and how they are shaped by learning and memory. To this end, we use computational models to elucidate the consequences of synaptic plasticity and neuronal dynamics on the levels of neurons, networks and systems.

Simone Spuler

Prof. Dr.

> Lab-Website
> Email

Prof. Dr. Simone Spuler

Affiliation

Charité - Universitätsmedizin Berlin, Experimental and Clinical Research Center, Muscle Research Unit, 13125 Berlin

Research area primary
clinical/translational

Research area secondary
cellular/molecular

Research Methods
experimental
cellular
clinical
molecular

Research Focus

Muscular dystrophies, adult muscle stem cells, gene editing, development of therapies for muscle wasting diseases, muscle aging, acquired myopathies like statin myopathy

Wilhelm Stannat

Prof. Dr.

> Lab-Website
> Email

Prof. Dr. Wilhelm Stannat

Affiliation

Technische Universität Berlin, Fakultät II - Mathematik und Naturwissenschaften, Institut für Mathematik, Bernstein Center for Computational Neuroscience, Marchstr. 23, 10587 Berlin

Research area primary
systems/cognitive

Research area secondary
cellular/molecular

Research Methods
computational
modelling
stochastic analysis

Research Focus

computational models for neural activity (micro - mezo - macroscopic) with noise and under uncertainty mean-field limits and fluctuation theory

Christoph Stein

Prof. Dr.

> Lab-Website
> Email

Prof. Dr. Christoph Stein

Affiliation

Charité - Universitätsmedizin Berlin, Klinik für Anaesthesiologie und operative Intensivmedizin, CBF, Hindenburgdamm 30, 12203 Berlin

Research area primary
clinical/translational

Research area secondary
systems/cognitive

Research Methods
clinical
cellular
experimental
electrophysiology
behavioral

Research Focus

Mechanisms and treatment of pain; opioid pharmacology; regulation/signalling of opioid receptors in sensory neurons; conformational dynamics of opioid receptor-ligand interactions; expression/processing of opioid peptides in inflammatory cells; nanocarrier-directed transport of opioids to injured tissues; permeability of skin, intestinal, blood-brain and perineurial barriers; clinical studies in patients with postoperative, arthritic and neuropathic pain; bioethics of pain treatment and opioid use

Philipp Sterzer

Prof. Dr.

> Lab-Website
> Email

Prof. Dr. Philipp Sterzer

Affiliation

Charité - Universitätsmedizin Berlin, Department of Psychiatry and Psychotherapy, CCM, 10117 Berlin

Research area primary
systems/cognitive

Research area secondary
clinical/translational

Research Methods
experimental
human brain imaging
computational
cognitive neuroscience

Research Focus

We use fMRI, psychophysics, eye tracking and computational modelling to study human visual perception. The main research focus is on understanding the neural basis of conscious visual perception and alterations of perceptual processes in mental diseases, with a focus on schizophrenia. Current projects use the computational framework of predictive coding to investigate the role of learning and expectations in the context of perceptual ambiguity, learing and decision making. Another focus of our research is on the unconscious processing of visual information.

Olaf Strauß

Prof. Dr.

> Lab-Website
> Email

Affiliation

Experimental Ophthalmology, Dept. of Ophthalmology, Charite University Medicine Berlin, Campus Virchow Clinic, Augustenburger Platz 1, 13353 Berlin

Research area primary
cellular/molecular

Research area secondary
clinical/translational

Research Methods
experimental
electrophysiology
molecular
interventional studies, cell physiology.

Research Focus

The retinal pigment epithelium (RPE) is a close interaction partner of photoreceptors and participates in visual function. As being part of the blood/retina barrier it establishes the immune privilege of the eye and is an interface to the body system. Changes in the function of the RPE ultimatively lead to retinal degeneration, among them the age-related macular degeneration represents on of most common causes for blindness in industrialized countries. We study mutation-dependent, immune-related and systemic-induced changes in RPE function that lead to loss of photoreceptors.

Ulf Strauß

PD. Dr.

> Lab-Website
> Email

Affiliation

Charité - Universitätsmedizin Berlin, Institute for Cell- and Neurobiology, 10117 Berlin

Research area primary
cellular/molecular

Research area secondary
clinical/translational

Research Methods
experimental
electrophysiology
modelling
cellular imaging

Research Focus

We study ionic mechanisms of normal functioning and pathology in the CNS. Past and recent projects range from modulation of potassium currents of encephalitogenic T-lymphocytes, ionic currents in developing neurons in striatum and cortex, neuronal excitability changes by cytokines, to disease mechanisms in epilepsy or hypokinetic, rigid syndromes. Apart from content-based research, we have always been interested in emerging technical possibilities in electrophysiology, particularly in patch clamping.

Victor Tarabykin

Prof. Dr.

> Lab-Website
> Email

Affiliation

Charité - Universitätsmedizin Berlin, Institute of Cell and Neurobiology, 10117 Berlin

Research area primary
cellular/molecular

Research Methods
experimental

Research Focus

We are interested in the cellular and molecular mechanisms underlying cell fate specification in the mouse cerebral cortex. We focus on the mechanisms controlling the generation, migration and axonal guidance of neurons of different cortical layers and areas. Our methods combine genetic, molecular and cell biological approaches to identify and characterize genes that control cortical development.

Baris Tursun

Dr.

> Lab-Website
> Email

Affiliation

Max Delbrück Center for Molecular Medicine Berlin, Institute for Medical Systems Biology (BIMSB), Robert-Rössle-Str. 10, 13125 Berlin

Research area primary
cellular/molecular

Research area secondary
clinical/translational

Research Methods
experimental
cellular
molecular

Research Focus

We use C. elegans as a genetic model organism to study the molecular basis of cell fate maintenance and protection in order to improve direct reprogramming of different cells into neurons. By imaging cellular reprogramming in vivo combined with visual genetic screens, we identified chromatin factors that safeguard cell fates and act as a barrier for direct reprogramming of non-neuronal cells to specific neurons. Together with our studies on the interconnection of Aging and cell fate protection our findings could help to overcome the limitations of Direct Reprogramming in other systems.

Daniela Vallentin

Ph.D

> Lab-Website
> Email

Ph.D Daniela Vallentin

Affiliation

Freie Universität Berlin, Institut f. Biologie Takustr. 6 14195 Berlin

Research area primary
systems/cognitive

Research Methods
experimental
electrophysiology
computational
small animal imaging

Research Focus

The process by which we learn through observation of others has been associated with the acquisition of a range of complex skilled behaviors in humans as well as some animal species. Zebra finches, for instance, learn to produce their songs by listening to and trying to imitate their father. The focus of our research is to examine the changes in the songbird brain that occur throughout development, in order to discover synaptic mechanisms that are critical for shaping observational learning for singing behavior. Thererfore, we am using electrophysiological recordings in awake behaving animals.

Alexander Walter

Dr.

> Lab-Website
> Email

Dr. Alexander Walter

Affiliation

Leibniz Institut für Molekulare Pharmakologie, Charité /CCO, Charitéplatz 1, 10117 Berlin

Research area primary
cellular/molecular

Research area secondary
systems/cognitive

Research Methods
experimental
cellular imaging
modelling
electrophysiology

Research Focus

Our Emmy Noether research group focusses on the molecular mechanisms of synaptic transmission, which underlies brain function. Synaptic transmission is remarkably well organized and optimized for faithful and fast information processing, but why synapses are so diverse in their input/output behavior and which molecular mechanisms underlie their plastic adaptation is insufficiently understood. Using experimental and theoretical approaches we aim to identify the molecular principles of synapse specialization and plasticity.

Henrik Walter

Prof. Dr.

> Lab-Website
> Email

Prof. Dr. Henrik Walter

Affiliation

Charité - Universitätsmedizin Berlin, Department of Psychiatry and Psychotherapy CCM, Charitéplatz 1, 10117 Berlin

Research area primary
systems/cognitive

Research area secondary
clinical/translational

Research Methods
experimental
human brain imaging
clinical
cognitive neuroscience

Research Focus

My clincal research focus is on the major psychoses (schizophrenia, depression, bipolar disorder) and alcohol use disorder, but I have investigates also other disorders, including autism, Alzheimer and pedophilia. A methodologicla focus is imaginggenetics (effects of disease realted genetic variants on brain function) and connectomis (graph theory, ICA). Basic neurocognitive research is in cignitive control, affect, stress, emotion regulatione, theory of mind, reward, and decision making. Furthermore, I work in philosophy of mind (free will), neuroehtics and philosophy of psychiatry.

Mathias Wernet

Prof. Dr.

> Lab-Website
> Email

Prof. Dr. Mathias Wernet

Affiliation

Freie Universität Berlin, Department of Biology, Division of Neurobiology, Takustr. 6, 14195 Berlin

Research area primary
cellular/molecular

Research area secondary
systems/cognitive

Research Methods
experimental
cellular imaging
computational
cellular
Behavior, Neuroethology Molecular Genetics

Research Focus

What are the functional contributions of defined cellular units to specific visual behaviors? Using Drosophila, we address this problem at multiple levels: 1). We describe the factors specifying particular neuronal cell fates and their morphology. 2). We characterize the necessity of these cells in the behaving animal, using molecular genetic circuit breaking tools. 3). We visualize their responses using genetically encoded activity indicators. Together, these synergistic experiments reveal the functional connectivity within different neuronal circuits informing distinct visual behaviors.

Thomas Willnow

Prof. Dr.

> Lab-Website
> Email

Prof. Dr. Thomas Willnow

Affiliation

Max Delbrück Center for Molecular Medicine, Robert-Rössle-Str. 10, 13125 Berlin

Research area primary
cellular/molecular

Research area secondary
clinical/translational

Research Methods
experimental
molecular
biochemical

Research Focus

We investigate orphan endocytic receptors in the nervous system to elucidate their relevance for development and functional integrity of the brain. Currently, we focus on a unique class of neuronal lipoprotein receptors, termed sortilins that emerge as major risk factors in psychiatric and neurodegenerative diseases, including Alzheimer’s disease and frontotemporal dementia. Using transgenic mouse and iPSC-derived human cell models, we study the molecular mechanisms of receptor action in brain (patho)physiology and develop therapeutic strategies for treatment of neurodegenerative diseases.

York Winter

Prof. Dr.

> Lab-Website
> Email

Affiliation

Humboldt Universität zu Berlin, Institut für Biologie, Philippstr. 13, 10115 Berlin, Germany

Research area primary
systems/cognitive

Research area secondary
clinical/translational

Research Methods
experimental
cognitive neuroscience
molecular
Automated behaviour quantification

Research Focus

We are interested in how behaviour adapts animals to the complex conditions of natural environments. We work with rats and mice and, for decision making under natural, ecological conditions, with flower-visiting bats. We also perform diagnostic tests in mouse and rat models of neurological and psychiatric diseases used in preclinical research in the Berlin Mouse Clinic for Neurology and Psychiatry a modern behavior diagnostic facility established within NeuroCure. Our engineering lab develops novel behaviour detection and experimentation technologies using computer-based automation technology.

F. Gregory Wulczyn

PD. Dr.

> Lab-Website
> Email

PD. Dr. F. Gregory Wulczyn

Affiliation

Charité - Universitätsmedizin Berlin, Institute for Cell and Neurobiology, Charitéplatz 1, 10117 Berlin

Research area primary
cellular/molecular

Research area secondary
clinical/translational

Research Methods
experimental
molecular
cellular

Research Focus

Stem cells are the cellular substrate for development and therefore our starting point for studying the design principles of the brain. We explore the regulatory terrain occupied by neuronal miRNAs, hoping to distill their molecular logic: how they are regulated and how they contribute to neural cell fates and functional maturation. We study novel miRNAs and their targets, employing molecular and cellular techniques: Protein-RNA and Protein-Protein interaction, iClip, Crispr/Cas, FACS, advanced imaging etc. on diverse models: ESC organoids, in utero electroporation and transgenic mice.

Ferah Yildirim

Prof. Dr.

> Lab-Website
> Email

Prof. Dr. Ferah Yildirim

Affiliation

Charité - Universitätsmedizin Berlin, Department of Neuropsychiatry at Department of Psychiatry and Psychotherapy, CCM, NeuroCure Cluster of Excellence, Charitéplatz 1, 10117 Berlin

Research area primary
cellular/molecular

Research area secondary
clinical/translational

Research Methods
experimental
molecular
computational
cellular

Research Focus

The overall goal of our research is to systematically evaluate epigenetic and gene expression changes in Huntington’s disease (HD) to identify the most critically-disrupted regulatory processes that are responsible for the aberrant gene expression patterns in HD. These processes become candidates for therapeutic testing in HD and potentially in other central nervous system conditions with converging pathogenic mechanisms. For this goal, our lab applies a combination of genome-wide DNA sequencing technologies with mechanistic and functional approaches to in vitro and mouse models of disease.

Niccolo Zampieri

Dr.

> Lab-Website
> Email

Dr. Niccolo Zampieri

Affiliation

Max Delbrück Center for Molecular Medicine, NeuroCure Cluster of Excellence, Robert-Rössle-Str. 10, 13125 Berlin

Research area primary
cellular/molecular

Research Methods
experimental
computational

Research Focus

I am interested in understanding the developmental mechanisms that control assembly and function of neural circuits. In particular, I focus on the role of neuronal position. Neuronal subtypes are found in discrete and invariant positions in the nervous system and not only share positional coordinates but typically receive common neural inputs and send projections to similar targets. By using a combination of molecular, genetic and anatomical tracing approaches we investigate the mechanisms controlling precise positioning and its relevance for the wiring of neural circuits.

Robert Zinzen

Dr.

> Lab-Website
> Email

Affiliation

Max Delbrück Center for Molecular Medicine Berlin, Institute for Medical Systems Biology (BIMSB), Robert-Rössle-Str. 10, 13125 Berlin

Research area primary
cellular/molecular

Research area secondary
systems/cognitive

Research Methods
experimental
molecular
computational
cellular
systems biology

Research Focus

Our group focuses on the gene regulatory mechanisms driving early nervous system development. Using Drosophila as a model organism, we focus on how the nervous system primordium is established with in the embryo, how this primordium subdivides and specifies into territories, and how these territories bring forth distinct sets of neuroblasts, which proliferate and differentiate. We utilize a systems approach by combining genomics, transcriptomics and proteomics techniques to understand gene regulation with temporal and tissue specificity in early development.