Location: Institute of Theoretical Biology
"Antidepressant Potential of the Psychedelic N,N-DMT: From Clinical Trials to Mechanisms and Challenges"
As part of the ongoing Student/Postdoc-Run Speaker Series (SPRSS), and on behalf of the Neural Mechanisms of Psychedelic Drug Action Group, Dr. Draulio Barros de Araujo from the Federal University of Rio Grande do Norte, Brazil, will give a talk titled "Antidepressant Potential of the Psychedelic N,N-DMT: From Clinical Trials to Mechanisms and Challenges." The talk can also be accessed via Zoom here.
Abstract: This lecture will explore the antidepressant potential of N,N-Dimethyltryptamine (DMT), a powerful psychedelic compound known for its rapid and profound effects on consciousness. Drawing from recent research conducted by our team, we will discuss recent clinical trials demonstrating DMT's safety, tolerability, and efficacy in treating depression, showcasing its ability to induce rapid and sustained improvements in depressive symptoms. Furthermore, the presentation will explore the underlying mechanisms of such antidepressant effects, particularly regarding behavior, neuroplasticity, inflammation, and stress. Additionally, we will address the challenges and ethical considerations of translating these findings into therapeutic contexts, particularly about dosage, administration, and patient safety. This lecture aims to provide a comprehensive overview of the journey from molecule to patient, offering insights into the future of psychedelic therapies in the treatment of depression.