Opiates and the brain

Brigitte L. Kieffer

Douglas Research Center, Dpt Psychiatry McGill University Montréal Canada
IGBMC, CNRS/INSERM/UdS Strasbourg France

Opiates have been used since thousand years for their remarkable pain-relieving and rewarding properties. Opiates produce their potent effects by activating opioid receptors in the brain, highjacking an endogenous opioid system. Here we will summarize current knowledge on opioid receptor function, as elucidated by genetic approaches, and present recent work on neural networks subserving opioid-controlled behaviors using connectome genetics in live animals.